{"id":112,"date":"2016-10-10T09:40:13","date_gmt":"2016-10-10T01:40:13","guid":{"rendered":"http:\/\/www.126dmea.com\/?p=112"},"modified":"2016-10-10T09:40:13","modified_gmt":"2016-10-10T01:40:13","slug":"synthesisandcrystalstructuresofchiral","status":"publish","type":"post","link":"https:\/\/shtaishengjx.com.cn\/index.php\/archives\/112","title":{"rendered":"Synthesis and Crystal Structures of Chiral"},"content":{"rendered":"<p>Abstract   N-(2-Bromopropionyl)-O-benzyl-L-serine  (BPBS)  was  prepared  using  2-bromopropionic  acid<br \/>\nand  N-Boc-O-Bzl-L-serine  as  the  starting  reagents.  BPBS  underwent  the  intra-molecular  ring-closing  reac-<br \/>\ntion  in  DMF\/Et<br \/>\n3<br \/>\nN  solvent  at  80  \u2103for  9  h  forming  a  mixture  of  two  non-enantiomers,  i.e.  (3S,6S)-benzyl-<br \/>\noxymethyl-6-methyl-morpholine-2,5-dione [(3S,6S)-BMMD] and (3S,6R)-BMMD with a yield of 70%. Two<br \/>\noptically pure enantiomers of BMMD, i.e. (3S,6S)-BMMD and (3S,6R)-BMMD were obtained via 4 opera-<br \/>\ntion  circles  of  \u201csolution-partial  recrystallization\u201d  by  means  of  a  differential  recrystallization  method  using<br \/>\nethyl acetate as a solvent. The single crystals of the two isomers of BMMD were grown from ethyl acetate at<br \/>\nroom  temperature.  The  fine  molecular  structures  of  the  two  isomers  were  determined  by  X-ray  diffraction<br \/>\nanalysis of the single crystals.<br \/>\nKeywords   (3S,6S)-benzyloxymethyl-6-methyl-morpholine-2,5-dione; (3S,6R)-benzyloxymethyl-6-methyl-<br \/>\nmorpholine-2,5-dione; resolution; optical isomer; crystal structure <\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract N-(2-Bromopropionyl)-O-benzyl-L-serine (BPBS) was prepared using 2-bromopropionic acid and N-Boc-O-Bzl-L-serine as the starting reagents. BPBS underwen &#8230;<\/p>\n","protected":false},"author":1,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[3],"tags":[],"_links":{"self":[{"href":"https:\/\/shtaishengjx.com.cn\/index.php\/wp-json\/wp\/v2\/posts\/112"}],"collection":[{"href":"https:\/\/shtaishengjx.com.cn\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/shtaishengjx.com.cn\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/shtaishengjx.com.cn\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/shtaishengjx.com.cn\/index.php\/wp-json\/wp\/v2\/comments?post=112"}],"version-history":[{"count":1,"href":"https:\/\/shtaishengjx.com.cn\/index.php\/wp-json\/wp\/v2\/posts\/112\/revisions"}],"predecessor-version":[{"id":113,"href":"https:\/\/shtaishengjx.com.cn\/index.php\/wp-json\/wp\/v2\/posts\/112\/revisions\/113"}],"wp:attachment":[{"href":"https:\/\/shtaishengjx.com.cn\/index.php\/wp-json\/wp\/v2\/media?parent=112"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/shtaishengjx.com.cn\/index.php\/wp-json\/wp\/v2\/categories?post=112"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/shtaishengjx.com.cn\/index.php\/wp-json\/wp\/v2\/tags?post=112"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}